LATEST RESEARCH FOR CRPS
This page has the latest research, study results, guidelines, news articles and new upcoming studies for Complex Regional Pain Syndrome (CRPS) that are available around the world. You will find the information is in three (3) different sections; Latest Research, Studies & Guidelines, New Studies & Trials and News Articles.
Latest Research for CRPS/RSD
LATEST RESEARCH, STUDIES & GUIDELINES
TREATMENT
Ahmad, F.M.H. & Kumar, K.V.S.H. (2015) ‘Failure to fire after an electrical injury – a complex syndrome in a soldier,’ Mil Med Res. 2015, March 28. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440596/> doi: 10.1186/s40779-015-0036-3
*NEW* Ahmed, S. et al. (2016) ‘Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Study of a Pregnant Female,’ Pain Physician. 2016, March. Vol 19(3), pp E487-493. FULL TEXT Available from: <http://www.painphysicianjournal.com/current/pdf?article=MjYyMg%3D%3D&journal=95>
Ahmed, S.U. et al. (2015) ‘Effect of 1.5% Topical Diclofenac on Clinical Neuropathic Pain,’ Anesthesiology. 8 May 2015. PMID: 25955980. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25955980?dopt=Abstract>
*NEW* Albayrak, I. et al. (2016) ‘Pulsed radiofrequency applied to the dorsal root ganglia for treatment of post-stroke complex regional pain syndrome: A case series,‘ Journal of Clinical Anesthesia. 2016, September. Vol 33, pp 192-197. Available from: <http://www.sciencedirect.com/science/article/pii/S0952818016300952>
*NEW* Alkosha, H.M. & Elkiran Y.M. (2016) ‘Predictors of long term outcome of thoracic sympathectomy in complex regional pain syndrome (CRPS) type 2,’ World Neurosurgery. 2016, May 4. pii: S1878-8750(16)30230-3. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27155377> doi: 10.1016/j.wneu.2016.04.101. Epub ahead of print
Apiliogullari, S. et al. (2015) ‘Pulsed Radiofrequency of Dorsal Root Ganglia for the Treatment of Complex Regional Pain Syndrome in an Adolescent with Poliomyelitis Sequel: A Case Report,’ Pain Medicine. 2015. Vol 16, pp 1369-1372. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/16/7/1369.full.pdf>
Aradillas, E. et al. (2015) ‘Plasma Exchange Therapy in patients with Complex Regional Pain Syndrome,’ Journal of American Society of Interventional Pain Physicians. July/August 2015. Vol 18 Issue 4. pp 383-394. Available from: <http://www.painphysicianjournal.com/crrent_issue_vw.php?journal=89&code=2374&issue=current_issue>
Atalay, N.S. et al (2014) ‘Prednisolone in complex regional pain syndrome,’ Pain Physician. 2014, March-April. Vol 17(2) pp 179-185. Available FULL TEXT from: <http://www.painphysicianjournal.com/current/pdf?article=MjA3NA%3D%3D&journal=81> PMID: 24658479
Barbalinardo, S et a;. (2015) ‘The treatment of long-standing Complex Regional Pain Syndrome with oral steroids,’ Pain Medicine. 2015, December 7. Vol 0, pp 1-7. Available FULL TEXT from: <http://painmedicine.oxfordjournals.org/content/painmedicine/early/2015/12/07/pm.pnv002.full.pdf>
Barnhoorn, K.J. et al (2015) ‘Are pain-related fears mediators for reducing disability and pain in patients with complex regional pain syndrome type 1? An explorative analysis on pain exposure physical therapy,’ NCBI NIH. 2015, 28 April; Vol 10 (4). e0123008. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25919011> doi: 10.1371/journal.pone.0123008
*NEW* Barry, M. (2016) ‘Efficacy of Pamidronate infusions for treatment of Complex Regional Pain Syndrome (CRPS),’ Prevention Care Recovery, New Zealand. Full Text Available From: <http://www.acc.co.nz/PRD_EXT_CSMP/groups/external_communications/documents/reports_results/wpc139026.pdf>
Breuer, A.J. et al. (2014) ‘Short-term treatment with parecoxib for complex regional pain syndrome: a randomized, placebo-controlled double-blind trial,’ Pain Physician. 2014, March-April. Vol 17(2) pp 127-137. Available FULL TEXT from: <http://www.painphysicianjournal.com/current/pdf?article=MjA2OA%3D%3D&journal=81> PMID: 24658473
Chopra, P & Cooper, S. (2013) ‘Treatment of Complex Regional Pain Syndrome using Low Dose Nalterxone (LDN)’ J Neuroimmune Pharmacol. 2013 Jun; Vol 8(3) pp.470–476. Available from <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661907/> doi: 10.1007/s11481-013-9451-y
Chou, R. et al. (2009) ‘Clinical Guidelines for the Use of Chronic Opioid Therapy In Chronic Noncancer Pain’ The Journal of Pain. 2009 February; Volume 10, Issue 2. pp 113-130 e.2. Available from: <http://www.jpain.org/article/S1526-5900(08)00831-6/abstract> doi: 10.1016/j.jpain.2008.10.008>
Connolly, S.B. et al. (2015) ‘A Systematic Review of Ketamine for Complex Regional Pain Syndrome,’ Pain Medicine. 2015. Vol 16, pp 943-969. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/16/5/943.full.pdf>
de Oliveira, R.R. et al. (2014) ‘Thoracic sympathetic block for the treatment of complex regional pain syndrome type I: a double-blind randomized controlled study,’ Pain. 2014, November. Vol 155(11), pp 2274-2281. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25149143> doi: 10.1016/j.pain.2014.08.015
*NEW* Deer, T.R. et al. (2017) ‘Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial’ Journal of International Study of Pain. 2017, April. Vol 158 Issue 4, pp 669-681. Full Text Available from: <http://journals.lww.com/pain/Fulltext/2017/04000/Dorsal_root_ganglion_stimulation_yielded_higher.14.aspx>
Douglas, S.R. et al. (2015) ‘Analgesic response to intravenous ketamine is linked to a circulating microRNA signature in female complex regional pain syndrome patients,‘ Journal of Pain. 10 June 2015. pii: S1526-5900(15)00700-2 Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26072390> doi: 10.1016/j.jpain.2015.05.008
Fischer, S.G.L. et al (2013) ‘Intravenous Magnesium for chronic Complex Regional Pain Syndrome Type I,’ Pain Medicine. 2013. Vol 14, pp 1388-1399. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/14/9/1388.full.pdf>
Fukumori, S. et al (2016) ‘Assessment of Motor Function in Complex Regional Pain Syndrome With Virtual Reality-based Mirror Visual Feedback: A Pilot Case Study,’ Neuroscience and Biomedical Engineering. Volume 4, Number 1, March 2016, pp. 43-49(7) Available from: < http://www.ingentaconnect.com/contentone/ben/nbe/2016/00000004/00000001/art00007>
Gillick, L. et al. (2016) ‘Successful Treatment of Complex Regional Pain Syndrome with Pseudoaneurysm Excision and Median Nerve Neurolysis,’ World Neurosurgery. 2016, June 15, pii: S1878-8750(16)30408-9. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27318309> PMID:2731830
Goebel, A. et al. (2014) ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. 2014, October 24. Vol 15:154. Available FULL TEXT from: <http://www.trialsjournal.com/content/pdf/1745-6215-15-404.pdf> doi: 10.1186/1745-6215-15-404.
Goebel, A. et al (2017) ‘Low-Dose Intravenous Immunoglobulin Treatment for Long-Standing Complex Regional Pain Syndrome: A Randomized Trial,’ Ann Intern Med. 2017 Oct 3. Vol 167(7); pp 476-483. Available from: <https://www.ncbi.nlm.nih.gov/pubmed/28973211>
UPDATE on Low Dose IVIG study – Promising treatment for Complex Regional Pain Syndrome ineffective
Goebel, A. et al (2014) ‘Treatment of long-standing complex regional pain syndrome with therapeutic plasma exchange: a preliminary case series of patients treated in 2008-2014,’ Pain Med. 2014. Vol 15(12), pp 2163-2164. Available from: <http://onlinelibrary.wiley.com/doi/10.1111/pme.12601/abstract> doi: 10.1111/pme.12601
*NEW* Goh, E.L. et al. (2017) ‘Complex regional pain syndrome: a recent update,’ Burns & Trauma. 2017, January 19. Vol 5, pp 5. Full Text Available From: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244710/>
Gierthmühlen J et al. (2014) ‘Mechanism-based treatment in complex regional pain syndrome’ Nat. Rev. Neurol. 2014 Sep; Vol 10(9) pp.518-528. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25134708> doi: 10.1038/nreurol.2014.140. Epub 2014 Aug 19
Guisti, A, & Bianchi, G. (2015) ‘Treatment of complex regional pain syndrome type I with bisphosphonates,’ RMD Open. 2015. Vol 1 Supp 1. FULL TEXT Available from: < http://rmdopen.bmj.com/content/1/Suppl_1/e000056.full.pdf+html> doi: doi:10.1136/rmdopen-2015- 000056
Hanlan, A.K. et al. (2014) ‘Early adjunct treatment with topical lidocaine results in improved pain and function in a patient with complex regional pain syndrome,’ Pain Physician. 2014, September-October. Vol 17(5), pp E629-635. Available FULL TEXT from: <http://www.painphysicianjournal.com/current/pdf?article=MjE2OA%3D%3D&journal=84> PMID: 25247913
Hendrickson, J.E. et al (2015) ‘Complex Regional Pain Syndrome and dysautonomia in a 14 year old girl responsive to therapeutic plasma exchange,‘ J Clinical Apher. 2015, May 23. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26011726> doi: 10.1002/jca.21407
*NEW* Henshaw, D.S. et al. (2016) ‘Ultrasound-Guided Continuous Superficial Radial Nerve Block for Complex Regional Pain Syndrome,’ J Pain Palliat Care Pharmacother. 2016, June. Vol 30(2) pp 118-123. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27159548> doi: 10.3109/15360288.2016.1173755. Epub 2016 May 9
Hosomi, K. et al (2013) ‘Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial,’ Pain. 2013, July. Vol 154(7), pp 1065-1072. Available FULL TEXT from: <http://www.sciencedirect.com/science/article/pii/S0304395913001115> doi: 10.1016/j.pain.2013.03.016. Epub 2013 Mar 15
Imani, F. et al. (2016) ‘Effectiveness of Stellate Ganglion Block Under Fuoroscopy or Ultrasound Guidance in Upper Extremity CRPS,‘ Journal of Clinical and Diagnostic Research. January 2016. Vol 10, issue 1. pp UC09-UC012. Full Text Available from: <http://www.jcdr.net/article_fulltext.asp?issn=0973-709x&year=2016&month=January&volume=10&issue=1&page=UC09&id=7035>
Kapoor, S (2012) ‘Vitamin C and its Emerging Role in Pain Management: Beneficial Effects in Pain Conditions Besides Post Herpetic Neuralgia,‘ NCBI NIH. 2012, Jul; Vol 25 (3) pp 200-201. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389328/ > doi: 10.3344/kjp.2012.25.3.200 Published Online 28 Jun 2012
*NEW* Kapural, L. et al (2016) ‘CREATE-1 study: a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of AXS-02 (disodium zoledronate tetrahydrate) administered orally to subjects with Complex Regional Pain Syndrome Type 1 (CRPS-1),’ Journal of Pain. 2016, April. Vol 17, Issue 4 Supplement. pp S81-S82. Available from: <http://www.jpain.org/article/S1526-5900(16)00436-3/pdf> doi: http://dx.doi.org/10.1016/j.jpain.2016.01.406
*NEW* Katznelson, R. et al. (2016) ‘Successful Treatment of Lower Limb Complex Regional Pain Syndrome following Three Weeks of Hyperbaric Oxygen Therapy,’ Pain Research and Management. 2016. Vol 2016, Article ID 3458371, 4 pages. Full Text Available from: <http://www.hindawi.com/journals/prm/2016/3458371/> doi: 10.1155/2016/3458371
Kim, J.M. et al (2014) ‘Bee Venom Pharmacopuncture: An Effective Treatment for Complex Regional Pain Syndrome,’ NCBI NIH & J Pharmacopuncture. 2014, Dec. Vol 17(4). pp 66-69. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332002/> doi: 10.3831/KPI.2014.17.039
Leuthold, B. et al. (2015) ‘Severe complex regional pain syndrome (CRPS) type I: A multidisciplinary treatment plan and intensive physiotherapy in pediatrics,’ Annals of Physical and Rehab Medicine. 2015, September. Vol 58 Supplement 1 pp e140. Available from: <http://www.sciencedirect.com/science/article/pii/S1877065715004169>
Lopez, E.O. et al. (2016) ‘Pain Relief in CRPS-II after Spinal Cord and Motor Cortex Simultaneous Dual Stimulation,’ Pain Physician. 2016, May. Vol 19(4), pp E631-635. FULL TEXT Available from: <http://www.painphysicianjournal.com/current/pdf?article=MjcyMQ%3D%3D&journal=96>
Manning, D.C. et al. (2014) ‘Lenalidomide for complex regional pain syndrome type 1: lack of efficacy in a phase II randomized study,’ J Pain. 2014, December.Vol 15(12) pp 1366-1376. Available FULL TEXT from: <http://www.jpain.org/article/S1526-5900(14)00940-7/pdf> doi: 10.1016/j.jpain.2014.09.013>
Onofrio, S. et al. (2016) ‘The Use of Transdermal Buprenorphine in Complex Regional Pain Syndrome: A Report of Two Cases,’ Journal of Pain Palliat Care Pharmacother. 2016, June. Vol 30(2) pp 124-127. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27172230>
Puchalski, P. & Zyluk, A. (2016) ‘Results of the Treatment of Chronic, Refractory CRPS with Ketamine Infusions: a Preliminary Report,’ Handchir Mikrochir Plast Chir. 2016, June. Vol 48(3), pp 143-147. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27311072> Epub 2016 Jun 16.
Russo, M & Van Buyten, J-P. (2015) ’10-kHz High-Frequency SCS Therapy: A Clinical Summary,’ Pain Medicine. 2015. Vol 16, pp 934-942. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/16/5/934.full.pdf>
Schu, B (2015) ‘Plasma Exchange may be effective treatment for CRPS,’ MD website. August 12, 2015. Available from: <http://www.hcplive.com/medical-news/plasma-exchange-may-be-effective-treatment-for-crps-patients>
Schwartz, R.G. (2014) ‘Stem Cells For The Treatment of Complex Regional Pain Syndrome (CRPS)/ Reflex Sympathetic Dystrophy (RSD): a case study,’ Pan American Journal of Medical Thermology. 2014. V 1 (2) pp 89-92. FULL TEXT Available from: <http://www.abraterm.com.br/revista/index.php/PAJTM/article/view/17/pdf_12>
Schwartzman, R.J. et al. (2012) ‘Ketamine as Adjunctive Anesthesia in Refractory Complex Regional Pain Syndrome Patients: A Case Series,’ J Clin Case Rep. 2012. Issue 2:12. Available from: < http://omicsgroup.org/journals/2165-7920/2165-7920-2-186.pdf>
Smart, KM et al. (2016) ‘Physiotherapy for pain and disability in adult patients with complex regional pain syndrome (CRPS) types I and II,’ Cochrane Review. 2016, Issue 2. Article No. CD010853. FULL TEXT Available from: <http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010853.pub2/epdf>
Tamburin, S. et al. (2014) ‘Immunoglobulin G for the Treatment of Chronic Pain: Report of an Expert Workshop,’ Pain Medicine. 2014. Vol 15, pp 1072-1082. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/15/7/1072.full.pdf>
Tesarz, J et al. (2014) ‘Effects of Eye Movement Desensitization and Reprocessing (EMDR) Treatment in Chronic Pain Patients: A Systematic Review,’ Pain Medicine. 2014. Vol 15, pp 247-263. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/15/2/247.full.pdf>
Varenna, M. et al. (2013) ‘Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study,’ Rheumatology (Oxford). 2013, March. Vol 52(3). pp 534-542. Available FULL TEXT from: <http://rheumatology.oxfordjournals.org/content/52/3/534.full.pdf+html> doi: 10.1093/rheumatology/kes312. Epub 2012 Nov 30
Wei, K. et al. (2014) ‘Ultrasound-Guided Stellate Ganglion Blocks Combined with Pharmacological and Occupational Therapy in Complex Regional Pain Syndrome (CRPS): A Pilot Case Series Ad Interim,’ Pain Medicine. 2014, December. Vol 15, pp 2120-2127. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/15/12/2120.full.pdf>
Whiteman, H, (2015) ‘Newly identified compounds in spider venom could help treat chronic pain,’ MNT online. 2015, March 4. Available from: <http://www.medicalnewstoday.com/articles/290338.php>
Won, AS. (2015) ‘Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS,’ Pain Med. 2015, August. Vol 16(8) pp 1644-1647. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25930099> doi: 10.1111/pme.12755
Yeo, Ji-Hee et al. (2015) ‘Repetitive Acupuncture Point Treatment with Diluted Bee Venom Relieves Mechanical Allodynia and Restores Intraepidermal Nerve Fiber Loss in Oxaliplatin-Induced Neuropathic Mice,’ Journal of Pain. Published online November 2015. Abstract Available from: <http://www.jpain.org/article/S1526-5900(15)00943-8/abstract> doi: http://dx.doi.org/10.1016/j.jpain.2015.10.018
Young, A.C. et al. (2015) ‘The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature,’ Regional Anesthesia and Pain Medicine. May/June 2015. Vol. 40 – Issue 3: pp 276–283. Available from: <http://mobile.journals.lww.com/rapm/_layouts/15/oaks.journals.mobile/articleviewer.aspx?year=2015&issue=05000&article=00013&ContextualNavigationType=search>
CAUSES and PHYSIOLOGICAL PROCESSES & FEATURES of CRPS
Barad M.J. et al (2014) ‘Complex Regional Pain Syndrome is associated with structural abnormalities in pain related regions of the human brain,‘ J Pain. February 2014. Vol 15(2). pp 197-203. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/24212070> doi: 10.1016/j.jpain.2013.10.011
Birklein, F. et al. (2015) ‘Activation of cutaneous immune responses in complex regional pain syndrome,’ Journal of Pain. 2014, May. Vol 15(5), pp 485-495. Full Text Available From: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011956/>
Birklein, F., Schlereth, T. (2015) ‘Complex regional pain syndrome—significant progress in understanding,’ Pain. 2015, April. Vol 156. pp S94-S103. Available from: < http://journals.lww.com/pain/Fulltext/2015/04001/Complex_regional_pain_syndrome_significant.13.aspx> doi: 10.1097/01.j.pain.0000460344.54470.20
Breivik, H. & Stubhaug, A. (2016) ‘Complex Regional Pain Syndrome (CRPS) after viper bite in pregnant young woman: Pathophysiology & Treatment options,’ Scandanavian Journal of Pain 10. 2016, pp 108-110. Full Text Available from: <http://www.scandinavianjournalpain.com/article/S1877-8860(15)00128-7/pdf>
Bruehl, S. (2010) ‘An Update on the pathophysiology of complex regional pain syndrome‘ NCBI NIH & Anesthesiology. 2010 Sep; Vol 113(3) pp 713-725 Available from: <http://www.ncbi.nlm.nih.gov/pubmed/20693883?log$=activity> doi: 10.1097/ALN.0b013e3181e3db38
Bruehl, S. (2015) ‘Complex Regional Pain Syndrome,’ BMJ. 2015; 351: h2730. Available from: <http://www.bmj.com/content/351/bmj.h2730> doi: dx.doi.org/10.1136/bmj.h2730
*NEW* Bruehl, S. et al. (2016) ‘Complex Regional Pain Syndrome (CRPS): evidence for warm and cold subtypes in a large prospective clinical sample,’ Pain. 2016, March 25 ahead of print. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/?term=Complex+regional+pain+syndrome+(CRPS):+evidence+for+warm+and+cold+subtypes+in+a+large+prospective+clinical+sample>
Carcamo, C.R. (2015) ‘Biomodal Modulation of Ipsilateral Spinal-Coeruleo-Spinal Pathway in CRPS: A Novekl Model for Explaining Different Clinical Features of the Syndrome,’ NCBI NIH & Pain Med. June, 9 2015. Available from: < doi: 10.1111/pme.12733
Casale, R. et al. (2015) ‘The words of pain in complex regional pain syndrome,’ Clinical Rheumatology. February 2015. Vol 29 Issue 1. pp 71-76. Available from: <http://www.bprclinrheum.com/article/S1521-6942%2815%2900041-8/abstract> doi: 10.1016/j.berh.2015.04.032
Christophe, L. et al (2016) ‘Prisms to Shift Pain Away: Pathophysiological and Therapeutic Exploration of CRPS with Prism Adaptation,’ Neural Plasticity. 2016, 7 September. Full Text Available from: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030434/>
Dirckx, M. et al. (2015) ‘The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I,’ Mediators of Inflammation. 2015. Vol 2015. Article ID 718201. Available FULL TEXT from: <http://www.hindawi.com/journals/mi/2015/718201/cta/> doi: dx.doi.org/10.1155/2015/718201
Dubois, E. et al. (2014) ‘Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors,’ Pain. 2014, Nov. Vol 155(11), pp 2408-2417. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/25250722> doi: 10.1016/j.pain.2014.09.022
Filippopulos, F.M. et al (2015) ‘Complex Regional Pain Syndrome (CRPS) or continuous unilateral distal experimental pain stimulation in healthy subjects does not bias visual attention towards one hemifield,’ Exp Brain Res. 2015, August 4. Epub ahead of print. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/26238407>
*NEW* Friesgaard, K.D. et al. (2016) ‘Persistent pain is common 1 year after ankle and wrist fracture surgery: a register-based questionnaire study,’ British Journal of Anaesth. 2016, May. Vol 116(5) pp 655-661. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27106969>
Galor, A. et al. (2015) ‘Neuropathic Ocular Pain due to Dry Eye Is Associated With Multiple Comorbid Chronic Pain Syndromes,’ Journal of Pain. Published online November 2015. Available from: <http://www.jpain.org/article/S1526-5900(15)00944-X/abstract> doi: http://dx.doi.org/10.1016/j.jpain.2015.10.019
Geha, P.Y. et al. (2008) ‘The brain in chronic CRPS pain: Abnormal gray-white matter interactions in emotional and autonomic regions,’ Neuron & Pub Med. 2008, November 26. Vol 60(4). pp 570-581. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637446/> doi: 10.1016/j.neuron.2008.08.022
Giannotti, S. et al. (2016) ‘Algodystrophy: Complex Regional Pain Syndrome and incomplete forms,’ Clin Cases Miner Bone Metab. 2016, Jan-April. Vol 13(1), pp 11-14. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869945/> doi: 10.11138/ccmbm/2016.13.1.011
*NEW* Goh, E.L. et al. (2017) ‘Complex Regional Pain Syndrome: A recent update’ Burns & Trauma. 2017. V5, p 2. Full Text Available from: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244710/> Published online 2017 Jan 19. doi: 10.1186/s41038-016-0066-4
Golmirzaie, G. MD et al. (2016) ‘Time Since Inciting Event Is Associated With Higher Centralized Pain Symptoms in Patients Diagnosed With Complex Regional Pain Syndrome,’ Regional Anesthesia and Pain Medicine. November/December 2016. Vol. 41 – Issue 6: pp 731–736. Available from: <http://mobile.journals.lww.com/rapm/_layouts/15/oaks.journals.mobile/articleviewer.aspx?year=2016&issue=11000&article=00014>
*NEW* Gorodkin, R. et al. (2016) ‘Microvascular response in patients with complex regional pain syndrome as measured by laser Doppler imaging,’ Microcirculation. 2016, April 26. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/27113962> Epub Ahead of Print
Hill, R.J. et al. (2012) ‘Rethinking the Psychogenic Model of Complex Regional Pain Syndrome: Somatoform Disorders and Complex Regional Pain Syndrome,’ Anesthesiology & Pain Medicine. 2012, July. Vol 2(2). pp 54-59. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821113/pdf/aapm-02-54.pdf> doi: 10.5812/aapm.7282
*NEW* Hotta, J. et al. (2016) ‘Abnormal brain responses to action observation in complex regional pain syndrome,’ Journal of Pain. 2016, November. Available from: <http://www.jpain.org/article/S1526-5900%2816%2930309-1/fulltext>
Kohr, D. et al. (2011) ‘Autoimmunity against the beta(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome,’ Pain. 2011, Dec. Vol 152(12). pp 2690-2700. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/21816540> doi: 10.1016/j.pain.2011.06.012.
Krammer, H.H. (2012) ‘Immunological aspects of the complex regional pain syndrome (CRPS),’ NCBI NIH & Curr Pharm Des. (2012) Vol 18(29). pp 4546-4549 Available from: <http://www.ncbi.nlm.nih.gov/pubmed/22612752>
Kuttikat, A. et al. (2016) ‘Neurocognitive and Neuroplastic Mechanisms of Novel Clinical Signs in CRPS,’ Frontiers in Human Neuroscience. 2016, 27 January. Vol 10, p 6. Full Text Available From: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728301/>
*NEW* Kuttikat, A. et al (2017) ‘Altered Neurocognitive Processing of Tactile Stimuli in Patients with Complex Regional Pain Syndrome (CRPS)’ Journal of Pain. 2017, December. Available from: <http://www.jpain.org/article/S1526-5900(17)30785-X/abstract>
Lutz, R. (2014) ‘Complex Regional Pain Syndrome may not be caused by trauma,’ MD website. 2014, July 28. Available from: <http://www.hcplive.com/medical-news/complex-regional-pain-syndrome-may-not-be-caused-by-trauma>
Mosely, L.G., & O’Connell, N.E. (2014) ‘Finding the balance in complex regional pain syndrome Expertise, optimism, and evidence,’ Neurology. Published online 2014, December. Vol 84, Issue 1. pp 19-20. Available from: < doi: 10.1212/WNL.0000000000001114
Maaike, D. et al (2015) ‘The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type 1,’ Mediators Inflamm. 2015, February. PMCID: PMC4337272 Published online 2015, February 8. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337272/> doi: 10.1155/2015/718201
Mailis-Gagnon, A. et al. (2014) ‘Characteristics of Complex Regional Pain Syndrome in Patients Referred to a Tertiary Pain Clinic by Community Physicians, Assessed by the Budapest Clinical Diagnostic Criteria,’ Pain Medicine. 2014, December. Vol 15, pp 1965-1974. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/15/11/1965.full.pdf>
Mainhofner, C. et al (2010) ‘Complex Regional Pain Syndromes: New pathophysiological concepts and therapies,’ Eur J Neurol. 2010, May. Vol 17 (5). pp 649-660 Available from: <http://www.ncbi.nlm.nih.gov/pubmed/20180838> doi: 10.1111/j.1468-1331.2010.02947
Marinus, J. et al. (2011) ‘Clinical features and pathophysiology of Complex Regional Pain Syndrome,’ The Lancet. 2011, July. Vol 10. Available from: <http://www.kompetenznetz-parkinson.de/mittwoch_900_1_CRPS_Lancet_Neurol_2011.pdf>
*NEW* Pendon, G. et al. (2016) ‘Complex Regional Pain Syndrome type 1: Analysis of 108 patients,’ Reumatol Clin. 2016, April 28. pii: S1699-258X(16)30009-2. Full Text Available from: <http://www.reumatologiaclinica.org/es/sindrome-doloroso-regional-complejo-tipo/avance/S1699258X16300092/>
Pepper, A. et al. (2013) ‘Complex Regional Pain Syndrome-Like Changes Following Surgery and Immobilization,’ Journal of Pain. 2013, May. Vol 14(5), pp 516-524. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644418/> doi: 10.1016/j.jpain.2013.01.004
Pleger, B. et al. (2014) ‘Complex Regional Pain Syndrome Type 1 affects Brain Structure in Prefrontal and Motor Cortex,‘ PLoS One. January 2014. Vol 9(1). e85372. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887056/>
Ratti, C. et al. (2015) ‘Post-traumatic complex regional pain syndrome: clinical features and epidemiology,’ Clinical Cases in Mineral and Bone Metabolism. 2015-Jan-April. Vol 12 Supplement 1, pp 11-16. Full Text Available From: < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832405/>
*NEW* Reimer, M et al. (2016) ‘Sensitization of the Nociceptive System in Complex Regional Pain Syndrome,’ PLoS One. 5 May 2016. Vol 11(4). e0154553. FULL TEXT Available from: <http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0154553.PDF> doi: 10.1371/journal.pone.0154553
Schilder, J.C. et al (2015) ‘Diurnal and nocturnal skin temperature regulation in complex regional pain syndrome,’ J Pain. 2015, March. Vol 16(3). pp 207-213. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/25481495> doi: 10.1016/j.jpain.2014.11.012
Shenker, N. et al. (2015) ‘Establishing the characteristics for patients with chronic Complex Regional Pain Syndrome: the value of the CRPS-UK Registry,’ British Journal of Pain. 2015, May. Vol 9 (2) pp 122-128. Available from: <http://bjp.sagepub.com/content/9/2/122.short>
Subedi, A. et al. (2011) ‘Complex Regional Pain Syndrome (CRPS type 1) in an adolescent following Extravasation of Dextrose containing fluid – an undiagnosed case,’ Korean Journal of Pain. 2011, June. Vol 24 No.2 pp 112-114. Available from: <http://synapse.koreamed.org/Synapse/Data/PDFData/0047KJP/kjp-24-112.pdf> doi: 10.3344/kjp.2011.24.2.112
Tajerian, M. et al (2015) ‘Sex Differences in a Murine Model of Complex Regional Pain Syndrome,’ NCBI NIH & Neurobiol Learn Mem. 9 June 2015. pii: S1074-7427(15)00107-0. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26070658> doi: 10.1016/j.nlm.2015.06.004
Tinastepe, N. (2015) ‘Complex regional pain syndrome,’ J American Dental Assoc. 2015, March. Vol 146, Issue 3. pp 200-202. Available from: < doi: 10.1016/j.adaj.2013.11.020
University of California – Davis (2015) ‘Key mechanism that causes neuropathic pain found,’ Science Daily. 7 July 2015. Available from: <http://www.sciencedaily.com/releases/2015/07/150707093353.htm>
University of Liverpool (2014) ‘Causes of serious pain syndrome closer to discovery,’ Science Daily. 2 July 2014. Available from: < http://www.sciencedaily.com/releases/2014/07/140702122531.htm>
*NEW* van Velzen G.A. et al. (2016) ‘Is the brain of complex regional pain syndrome patients truly different?’ European Journal of Pain. 10 May 2016. Ahead of Print. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27161331> DOI: 10.1002/ejp.882
Varenna, M. & Zucchi, F. (2015) ‘Algodystrophy: recent insight into the pathogenic framework,’ Clinical Cases Miner Bone Metab. 2015, January – April. Vol 12(1), pp 27-30. Available FULL TEXT from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469222/> doi: 10.11138/ccmbm/2015.12.1.027
Wild, D (2015) ‘Researchers continue to look for basic understanding of CRPS causes,’ No Pain Hanna website. 17 July 2015. Available from: <http://www.nopainhanna.com/researchers-continue-to-look-for-basic-understanding-of-crps-causes/?fb_action_ids=140180102984261&fb_action_types=rightrelevance%3Adiscover>
Zhou, G. et al. (2015) ‘Enlargement of choroid plexus in complex regional pain syndrome,’ Scientific Reports 5. Article number: 14329 (2015). Available FULL TEXT from: <http://www.nature.com/articles/srep14329> doi: 10.1038/srep14329
DIAGNOSIS & PROGNOSIS
Bean, D.J. et al. (2014) ‘The Outcome of Complex Regional Pain Syndrome: A systemic Review’ The Journal of Pain. 2014, July; Vol.15 Issue 7 pp 677-690. Available from: <http://www.jpain.org/article/S1526-5900(14)00565-3/abstract> doi: 10.1016/j.jpain.2014.01.500
Bean, D.J. et al. (2015) ‘Do psychological factors influence recovery from Complex Regional Pain Syndrome Type I? A prospective study,’ Pain. 2015, July 1. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26133727> PMID:26133727
Breivik, H. & Stubhaug, A. (2016) ‘Importance of early diagnosis of Complex Regional Pain Syndrome (CRPS I and CRPS II) : Delayed diagnosis of CRPS is a major problem,’ Scandinavian Journal of Pain. 2016. Vol 11, pp 49-51. Full Text Available from: <http://www.scandinavianjournalpain.com/article/S1877-8860(15)00129-9/pdf>
Bruehl, S. et al. (2016) ‘Complex regional pain syndrome (CRPS): evidence for warm and cold subtypes in a large prospective clinical sample,’ Pain. March 2016. Ahead of Print. Available from: <http://journals.lww.com/pain/Abstract/publishahead/Complex_regional_pain_syndrome__CRPS____evidence.99547.aspx>
Goebel, A. et al. (2014) ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. 2014, October 24. Vol 15:154. Available FULL TEXT from: <http://www.trialsjournal.com/content/pdf/1745-6215-15-404.pdf> doi: 10.1186/1745-6215-15-404.
Lunden, L.K. et al. (2016) ‘Delayed diagnosis and worsening of pain following orthopaedic surgery in patients with Complex Regional Pain Syndrome (CRPS),’ Scandanavian Journal of Pain 11. 2016, pp 27-33. Full Text Available from: < http://www.scandinavianjournalpain.com/article/S1877-8860(15)00124-X/pdf>
*NEW* Kuttikat, A. et al. (2017) ‘Novel Signs and Their Clinical Utility in Diagnosing Complex Regional Pain Syndrome (CRPS): A Prospective Observational Cohort Study,’ Clinical Journal of Pain. June 2017 – Volume 33 – Issue 6 – p 496–502
COMPLICATIONS OR SIDE EFFECTS of CRPS
Lee, D.H. et al (2014) ‘Risk Factors for Suicidal Ideation among Patients with Complex Regional Pain Syndrome,’ Psychiatry Investigation. 2014, January. Vol 11(1) pp 32-38. Available FULL TEXT from: <http://psychiatryinvestigation.org/html/fulltext.asp?no=0502014005&m=0> doi: 10.4306/pi.2014.11.1.32. Epub 2013 Oct 16
*NEW* Qureshi, A.A. & Friedman, A.J. (2018) “Complex Regional Pain Syndrome: What the Dermatologist Should Know,” Journal of Drugs in Dermatology. May 2018. Vol 17, Issue 5, pp 532. Available from: < http://jddonline.com/articles/dermatology/S1545961618P0532X>
Schwartzman, R.J. (2012) ‘Systemic Complications of Complex Regional Pain Syndrome,’ Neuroscience & Medicine. 2012. Vol 3. pp 225-242. Available from: <http://file.scirp.org/Html/22695.html> doi: 10.4236/nm.2012.33027
CRPS in CHILDREN
Boyraz, I. et al (2016) ‘A Child Patient Followed-up with the Diagnosis of Recurrent Complex Regional Pain Syndrome,’ Turkish Journal of Osteoporosis. 2016. Vol 22, pp 47-9. Full Text Available from: <http://cms.galenos.com.tr/FileIssue/9/945/article/47-49.pdf>
Dietz, F.R. & Compton, S. (2015) ‘Outcomes of a Simple Treatment for Complex Regional Pain Syndrome Type I in Children,’ Iowa Orthop Journal. 2015. Vol 35, pp 175-180. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492150/pdf/IOJ_2015_175.pdf>
Gharaei, H. (2015) ‘Continuous Peripheral Nerve Catheters in Pediatric Complex Regional Pain Syndrome,’ Anesth Pain Med. 2015, February. Vol 5 (1) e23414. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350163/> doi: 10.5812/aapm.23414
Leuthold, B. et al. (2015) ‘Severe complex regional pain syndrome (CRPS) type I: A multidisciplinary treatment plan and intensive physiotherapy in pediatrics,’ Annals of Physical and Rehab Medicine. 2015, September. Vol 58 Supplement 1 pp e140. Available from: <http://www.sciencedirect.com/science/article/pii/S1877065715004169>
Parker, R. et al (2018) “An Integrative Review of Interventions to Support Parents When Managing Their Child’s Pain at Home“ Pain Management Nursing. April 2018. Vol 19, Issue 2, Pages 139-156. Available from: <https://www.sciencedirect.com/science/article/pii/S1524904217303417>
Pedemonte, S. et al (2015) ‘Complex regional pain syndrome type i. An analysis of 7 cases in children,’ Neurologia. 2015, July-August. Vol 30(6), pp 347-351. Available FULL TEXT from: <http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=90434137&pident_usuario=0&pcontactid=&pident_revista=495&ty=103&accion=L&origen=zonadelectura&web=www.elsevier.es&lan=en&fichero=495v30n06a90434137pdf001.pdf> doi: 10.1016/j.nrl.2013.12.016. Epub 2014 Jun 18
Rodriguez-Lopez, M.J. et al (2015) ‘Complex Regional Pain Syndrome in Children: a multidisciplinary approach and Invasive Techniques for the management of nonresponders,’ Pain Practice. 2015, 11 June. Available from: <http://onlinelibrary.wiley.com/enhanced/doi/10.1111/papr.12317/> doi: 10.1111/papr.1231
Rodriguez, M.J. et al. (2015) ‘Invasive Management for Pediatric Complex Regional Pain Syndrome: Literature Review of Evidence,’ Pain Physician. 2015, Nov. Vol 18(6), pp 621-630. FULL TEXT Available from: <http://www.painphysicianjournal.com/current/pdf?article=MjQ1OA%3D%3D&journal=92>
Saltik, S. et al. (2016) ‘Pregabalin Treatment of a Patient With Complex Regional Pain Syndrome,’ Paediatric Neurol. 2016, January. Vol 54, pp 88-90. FULL TEXT Available from: <http://www.pedneur.com/article/S0887-8994(14)00016-2/pdf> doi: 10.1016/j.pediatrneurol.2014.01.015
Stevenson Won, A. (2015) ‘A Virtual Balloon-Popping Task for Kids with CRPS,’ Body In Mind website. 25 August 2015. Available from: <http://www.bodyinmind.org/virtual-reality-kids-crps/>
Wager, J. et al. (2015) ‘Psychological distress and stressful life events in pediatric complex regional pain syndrome,’ Pain Res Management. 2015, July-August. Vol 20(4), pp 189-194. Available FULL TEXT from: <http://www.pulsus.com/journals/pdf_frameset.jsp?jnlKy=7&atlKy=13480&isArt=t&jnlAdvert=Pain&adverifHCTp=&sTitle=Psychological%20distress%20and%20stressful%20life%20events%20in%20pediatric%20complex%20regional%20pain%20syndrome%2C%20Pulsus%20Group%20Inc&VisitorType=&pdfType=fulltextpdf> Epub 2015 Jun 2.#
Weissman, R. & Uziel, Y. (2016) ‘Pediatric complex regional pain syndrome: a review,’ Pediatr Rheumatol Online Journal. 2016, April 29. Vol 14(1) pp 29. Full Text Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850724/> doi: 10.1186/s12969-016-0090-8
AMPUTATION and CRPS
Amputation for Complex Regional Pain Syndrome still remains a very controversial subject amongst the medical and legal communities. Here are some research studies about amputation for CRPS:
Bodde, M.I. et al. (2014) ‘Informed Decision-Making Regarding Amputation for Complex Regional Pain Syndrome Type I,’ Journal of Bone Joint Surgery Am. 2014. Vol 96, pp 930-4. Full Text Available from: <https://www.researchgate.net/profile/Jan_Geertzen/publication/262847014_Informed_Decision-Making_Regarding_Amputation_for_Complex_Regional_Pain_Syndrome_Type_I/links/53f712670cf22be01c4530ae.pdf>
Bodde, M.I. et al. (2014) ‘Resilience in patients with amputation because of Complex Regional Pain Syndrome type I,’ Disability and Rehabilitation. 2012. Vol 36 issue 10, pp 838-843. Full Text Available from: <https://www.researchgate.net/profile/Pieter_Dijkstra2/publication/255732128_Resilience_in_patients_with_amputation_because_of_Complex_Regional_Pain_Syndrome_type_I/links/543f94e60cf23da6cb5b39c8.pdf>
Geertzen, J.H.B. et al. (2014) ‘Peripheral nerve pathology in patients with severely affected complex regional pain syndrome type I,’ International Journal of Rehabilitation Research. 2014. Full Text Available from: <https://www.researchgate.net/profile/Jan_Geertzen/publication/268984263_Peripheral_nerve_pathology_in_patients_with_severely_affected_Complex_regional_pain_syndrome_type_I/links/54d9ed480cf25013d0436bec.pdf>
Midbari, A. et al. (2016) ‘Amputation in patients with Complex Regional Pain Syndrome – a comparative study between amputees and non-amputees with intractable disease,’ The Bone and Joint Journal. 2016, April. Available from: <>http://www.bjj.boneandjoint.org.uk/content/98-B/4/548
GUIDELINES for CRPS
NETHERLANDS – Netherlands Society of Anaesthesiologists & Netherlands Society of Rehabilitation Specialists (November 2014) ‘Updated EBGD Guidelines for Complex Regional Pain Syndrome Type 1 2014,’ Full Guidelines Available from: <http://pdver.atcomputing.nl/pdf/Executive_summary_updated_guidelines_CRPS_I_2014.pdf>
UK – Royal College of Physicians (December 2011) ‘UK Guidelines for diagnosis, Referral & Management in Primary & Secondary Care, Complex Regional Pain Syndrome in Adults,’ Available from: < https://www.rcplondon.ac.uk/resources/complex-regional-pain-syndrome-guidelines>
USA – American Academy of Pain Medicine (2013) ‘Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 4th Edition,‘ Pain Medicine. 2013, Vol 14. pp 180-229. Available from: <http://onlinelibrary.wiley.com/doi/10.1111/pme.12033/epdf>
Latest News of Studies for CRPS/RSD
NEW STUDIES & TRIALS
> CRPS RESEARCH STUDY FOR TREATMENT – This Study is open after 31st March 2015 for sufferers of CRPS/RSD Type I and who are based in the USA. The doctors will be comparing and learning about a trial drug aimed specifically for CRPS/RSD called Neridronic Acid. They will compare 2 different doses of Neridronic Acid with placebo in various Type I sufferers around the USA. You can contact the Study group and see if there is a doctor in your area who is taking part in this study -> STUDY CRPS NOW 2015 Available from: <http://www.studycrpsnow.com/>
> Redecker, J. 26 April 2015, ‘Lacey Doctor seeks subjects for non-narcotic pain control study,’ Study sponsored by the University of Washington. Written in The Bellingham Herald. Available from: <http://www.bellinghamherald.com/2015/04/26/4261680_lacey-doctor-seeks-subjects-for.html?rh=1> This is the groundwork study being arranged by a Lacey Doctor named LUCINDA GRANDE. It is going to be a small study as the groundwork to a National Institutes of Health study later on.
> MYCOPHENOLATE TREATMENT for LONGSTANDING COMPLEX REGIONAL PAIN SYNDROME (MYPS I) – NOW CLOSED (As of 11 January 2015) – This is a UK study funded by the Pain Relief Foundation and sponsored by Aintree University Hospitals NHS Foundation Trust. The Chief Investigator; Dr Andreas Goebel is looking at a drug called Mycophenolate that has only just started being used for pain as it traditionally is used for other health conditions. He believes that as it already treats the immune system and it is known that CRPS is involved in the immune system that the drug could help longstanding CRPS sufferers. When results are out they will be included on this page.
> CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zolendronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) This study is being run by Axsome Therapeutics Inc in USA. There are some conditions attached before you can be considered as a candidate. Visit the web link above to find out more. The trial bulletin is available from: <https://trialbulletin.com/lib/entry/ct-02504008> This study is now in PHASE 3: < http://www.biospace.com/News/axsome-announces-enrollment-of-the-first-patient/387523>
> CREATE-1 Clinical Study – This is the Axsome Therapeutics CREATE-1 CRPS CLINICAL STUDY TRIAL website. Please visit this site to see if you qualify for their trial. There are trials for this CREATE-1 CRPS going on in various parts of the USA, Australia and also the UK. To see if there is a CREATE-1 trial going on near you, visit the LOCATIONS page to find out. Available from: <http://www.crpstrial.com/index.htm>
UK LOCATIONS for CREATE-1 CRPS clinical study are:
> Goebel, A. et al. closed 30 November 2015 ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. According to the Trials page for the LIPS trial, it states that:
“LIPS is a multicentre (United Kingdom), double-blind, randomised parallel group, placebo-controlled trial, designed to evaluate the efficacy, safety, and tolerability of intravenous immunoglobulin (IVIg) 0.5 g/kg plus standard treatment, versus matched placebo plus standard treatment in 108 patients with longstanding complex regional pain syndrome.”
“A study published by researchers at the University’s Institute of Translational Medicine, in Annals of Internal Medicine, has shown a potential treatment for patients with Complex Regional Pain Syndrome (CRPS) is ineffective.”
> UPDATE on T-121 drug currently being developed by Thar Pharmaceuticals in Pittsburg, USA. The FDA have given Thar approval for a Phase 3 clinical trials for their drug for CRPS; T-121 which is the oral form of Novartis’ intravenous-only zoledronic acid, which is sold under the brand name Zometra. This is good news for CRPS sufferers however the drug won’t be entering the market until approximately 2019.
Latest News for CRPS/RSD
NEWS ARTICLES
PAIN MANAGEMENT & TREATMENT
Ansorge, R. 20th March 2015 ‘Ozone Therapy: Hope for Chronic Illness’ Newsmax Health. Available from: <http://www.newsmax.com/Health/Health-News/ozone-therapy-treatment-cancer/2015/03/20/id/631395/>
Buxton, S. 7 October 2016 ‘Exploring patients’ opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study,’ PhysioSpot. Available from: <http://www.physiospot.com/research/exploring-patients-opinions-of-activity-pacing-and-a-new-activity-pacing-questionnaire-for-chronic-pain-andor-fatigue-a-qualitative-study/>
Coghlin, Ed 10th April 2105. ‘ WHAT IS THE STATE OF PAIN MANAGEMENT? National Pain Report. Available from: <http://nationalpainreport.com/what-is-the-state-of-pain-management-8825926.html>This article from the National Pain Report following the National Institutes of Health chronic pain strategy. In this they ask some expert doctors to comment on the question ‘What is the state of pain management?’ Read the article to discover more.
Deer, T.R. et al. (2015) ‘Case Report 7: Dorsal Root Ganglion Stimulation for The Treatment of Neuropathic Foot And Hand Pain,’ Pain Medicine News website. 2015, December 28. Available from: <http://painmedicinenews.com/Review-Articles/Article/12-15/Case-Report-7-Dorsal-Root-Ganglion-Stimulation-for-The-Treatment-of-Neuropathic-Foot-And-Hand-Pain/34540>
Drummond, P. (2015) ‘Sympathetic blocks for complex regional pain syndrome,’ Body In Mind website. 1 May 2015. Available from: <http://www.bodyinmind.org/sympathetic-blocks-crps/>
Frei, R. April 2015 Vol.13(4). ‘More Novel Technologies emerging in SCS’ Pain Medicine News. Available from: <http://www.painmedicinenews.com/ViewArticle.aspx?ses=ogst&d=Interventional+Pain+Medicine&d_id=353&i=April+2015&i_id=1167&a_id=30933#.VSZmYFCPhho.facebook> The world of Spinal Cord Stimulators is beginning to become a large target market for research companies wanting better SCS products for the large number of sufferers worldwide.
Leung, M. April 2015 Vol 13(4). ‘Risk Factors Elucidated for early dose Escalation in Long Term Opioid Therapy’ Pain Medicine News. Available from: < http://www.painmedicinenews.com/ViewArticle.aspx?ses=ogst&d=Clinical+Pain+Medicine&d_id=82&i=April+2015&i_id=1167&a_id=30932#.VSZm1A0KhPE.facebook>
Mangione, A.S. et al. (2016) ‘Nonparalytic botulinum molecules for the control of pain,’ Pain. May 2016.Vol 157. Issue 5, pp 1045-1055. FULL TEXT Available from: <http://journals.lww.com/pain/Fulltext/2016/05000/Nonparalytic_botulinum_molecules_for_the_control.9.aspx?platform=hootsuite> doi: 10.1097/j.pain.0000000000000478
Pearlman, J. 15 October 2015. ‘Cure for chronic pain found: World’s first as patient fitted with permanent spinal cord implant,’ Telegraph news online. Available from: <http://www.telegraph.co.uk/news/worldnews/australiaandthepacific/australia/11932938/Cure-for-chronic-pain-found-World-first-as-patient-fitted-with-permanent-spinal-cord-implant.html>
Straube, S. et al. 6th May 2015. ‘Vitamin D for the treatment of chronic painful conditions in adults,’ Cochrane. Available from: <http://www.cochrane.org/CD007771/SYMPT_vitamin-d-for-the-treatment-of-chronic-painful-conditions-in-adults?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+NewAndUpdatedSummaries+%28New+and+updated+Cochrane+summaries%29>
Stevenson Won, A. (2015) ‘A Virtual Balloon-Popping Task for Kids with CRPS,’ Body In Mind website. 25 August 2015. Available from: <http://www.bodyinmind.org/virtual-reality-kids-crps/>
PATHOPHYSIOLOGY & SPREADING
Denk, F et al (2016) ‘Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain,’ Cell Reports. FULL TEXT Available from: <http://www.cell.com/cell-reports/pdf/S2211-1247(16)30507-1.pdf> doi: http://dx.doi.org/10.1016/j.celrep.2016.04.063
Galor, A. et al. (2015) ‘Dry Eye’ Lined to Chronic Pain Syndromes,’ University of Miami Miller School of Medicine. December 2015. Available from: <http://med.miami.edu/news/dry-eye-linked-to-chronic-pain-syndromes>
Goebel, A. (2015) ‘Specific autoantibodies in patients with longstanding CRPS,’ Body In Mind website. 7th July 2015. Available from: < http://www.bodyinmind.org/autoantibodies-crps/>
Gordon, D. (2009) ‘More than a Feeling,’ Neurology Now. 2009, March/April. Vol 5 Issue 2. pp 18-19, 23-25. Available from: <http://journals.lww.com/neurologynow/Fulltext/2009/05020/More_Than_a_Feeling.17.aspx> doi: 10.1097/01.NNN.0000351335.65015.f4
King’s College, London. 12 May 2016. ‘Cells carry ‘memory’ of injury, which could reveal why chronic pain persists,’ KCL website. Available from: <http://www.kcl.ac.uk/ioppn/news/records/2016/May/Cells-carry-memory-of-injury,-which-could-reveal-why-chronic-pain-persists.aspx>
Schwartzman, R. MD 1st April 2013. ‘Complex Regional Pain Syndrome: Systemic Complications’ Practical Pain Management. Available from: <http://www.practicalpainmanagement.com/pain/complex-regional-pain-syndrome-systemic-complications> This article by a medical doctor is a very interesting and detailed article discussing the areas of the body that can be affected by CRPS/RSD such as the heart, chest pain, respiratory and others.
Schwartzman, R. MD 1 March 2010. ‘Deconstructing Complex Regional Pain Syndrome’ Practical Pain Management. Available from: <http://www.practicalpainmanagement.com/pain/neuropathic/crps/deconstructing-complex-regional-pain-syndrome> This article talks of the progression in the understanding of the basics of CRPS which may eventually take researchers to new medication and treatment.
Saint Louis University Medial Center 16 April 2015 ‘SLU Researchers Show that A3 Adenosine Receptor Can Activate “Off Signals” for Pain‘ Newswise. Available from: <http://www.newswise.com/articles/slu-researchers-show-that-a3-adenosine-receptor-can-activate-off-signals-for-pain#>
MISCELLANEOUS
Bean, D. (2015) ‘Could your state of mind influence CRPS recovery?’ Body In Mind website. 9th October 2015. Available from: <http://www.bodyinmind.org/factors-affecting-crps-recovery/>
Coole, C. et al. (2013) ‘Supporting Workers with Musculoskeletal Conditions: A Survey of United Kingdom Occupational Therapists’ Communications with Clients and Their Employers,’ British Journal of Occupational Therapy. November 2013. Vol. 76 no. 11478-486. Available from: <http://bjo.sagepub.com/content/76/11/478.abstract>
Fiore, K. 4th April 2015. ‘IS PAIN A PUBLIC HEALTH CRISIS?‘ MedPage Today. Available from: <http://www.medpagetoday.com/PainManagement/PainManagement/50826> This is an interesting article by MedPage Today, about whether chronic pain is a public health crisis in the USA. However the same question could be applicable around the world, what are your thoughts? Is Pain A Public Health Crisis?
Farell, J. (7th April 2015) ‘Hidden Disabilities and employer obligations under DDA‘ HR.BLR.COM(R) 2015 April. Available from: <http://hr.blr.com/HR-news/Discrimination/Disabilities-ADA/Hidden-disabilities-employer-obligations-under-ADA#> This is a good article written by a lawyer which outlines the employer obligations under the USA DDA about hidden disabilities of which CRPS/RSD is one.
Goebel, A. (2014) ‘Chronic Pain isn’t all in the brain, which is good news for sufferers,’ The Conversation. 2014, November 25. Available from: <http://theconversation.com/chronic-pain-isnt-all-in-the-brain-which-is-good-news-for-sufferers-34632>
Hannibal, K.E. & Bishop, M.D. (2014) ‘Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation,’ Physical Therapy. 2014, December. Vol 94(12), pp 1816-1825. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/?report=reader>
Jackson, T. et al. (2012) ‘Light Retrograde Massage for the Treatment of Post-Stroke Upper Limb Oedema: Clinical Consensus Using the Delphi Technique,’ British Journal of Occupational Therapy. December 2012. Vol. 75 no. 12549-554. Available from: <http://bjo.sagepub.com/content/75/12/549.abstract>
Malcangio, M. (2016) ‘Microglia and Chronic Pain,’ Pain. May 2016. Vol 157 Issue 5, pp. 1002-1003. FULL TEXT Available from: <http://journals.lww.com/pain/Fulltext/2016/05000/Microglia_and_chronic_pain.4.aspx?platform=hootsuite> DOI: 10.1097/j.pain.0000000000000353 This article concluded that: “Further studies comparing and contrasting microglial mechanisms in peripheral nerve injury and inflammation will help delineate shared and specific pathways for chronic pain conditions. At the same time, this line of research will yield innovative targets for the development of analgesic therapies for patients’ benefit.”
We hope you have found this page interesting for the Latest Research in the world of CRPS. Research evolves and updates very quickly and all of the time. This page highlights the most important latest research that is available.
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Last Updated: 13/06/2018
