Last Updated: 17th April, 2019
2019-04-17 LATEST RESEARCH FOR CRPS This page has the latest CRPS research, study results, guidelines, news articles and new upcoming studies for Complex Regional Pain Syndrome (CRPS) that are available around the world. You will find the information is in four (4) different sections; Latest Research, Studies & Guidelines, New CRPS Studies & Trials and News Articles
Latest Research for CRPS/RSD
LATEST RESEARCH – CRPS CLINICAL TRIALS NEW STUDIES & TRIALS > Grunenthal Phase III CRPS Clinical Trial – St. Pancras Clinical Research is trialing Neridronate infusions for Complex Regional Pain Syndrome (CRPS). Please learn more about the trial via
St. Pancras Clinical Research .
> CRPS RESEARCH STUDY FOR TREATMENT – This Study is open after 31st March 2015 for sufferers of CRPS/RSD Type I and who are based in the USA. The doctors will be comparing and learning about a trial drug aimed specifically for CRPS/RSD called Neridronic Acid. They will compare 2 different doses of Neridronic Acid with placebo in various Type I sufferers around the USA. You can contact the Study group and see if there is a doctor in your area who is taking part in this study -> STUDY CRPS NOW 2015 Available from: <http://www.studycrpsnow.com/>
> CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zolendronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) This study is being run by
Axsome Therapeutics Inc in USA. There are some conditions attached before you can be considered as a candidate. Visit the web link above to find out more. The trial bulletin is available from: <https://trialbulletin.com/lib/entry/ct-02504008>
This study is now in PHASE 3: < http://www.biospace.com/News/axsome-announces-enrollment-of-the-first-patient/387523>
> CREATE-1 Clinical Study – This is the
Axsome Therapeutics CREATE-1 CRPS CLINICAL STUDY TRIAL website . Please visit this site to see if you qualify for their trial. There are trials for this
CREATE-1 CRPS going on in
various parts of the USA, Australia and also the UK . To see if there is a CREATE-1 trial going on near you, visit the
LOCATIONS page to find out. Available from: <http://www.crpstrial.com/index.htm>
UK LOCATIONS for CREATE-1 CRPS clinical study are: Warrington Hospital, Warrington
Darlington Memorial Hospital, Darlington Royal Victoria Infirmary, Newcastle upon Tyne Norfolk and Norwich University Hospital, Norwich Guy’s and St. Thomas’ Hospital Pain Clinic, London Queen Elizabeth University Hospital, Glasgow > Goebel, A. et al. closed 30 November 2015 ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. According to the Trials page for the
LIPS trial, it states that:
“LIPS is a multicentre (United Kingdom), double-blind, randomised parallel group, placebo-controlled trial, designed to evaluate the efficacy, safety, and tolerability of intravenous immunoglobulin (IVIg) 0.5 g/kg plus standard treatment, versus matched placebo plus standard treatment in 108 patients with longstanding complex regional pain syndrome.”
UPDATE on LIPS IVIg Trial : “A study published by researchers at the University’s Institute of Translational Medicine, in Annals of Internal Medicine, has shown a potential treatment for patients with Complex Regional Pain Syndrome (CRPS) is ineffective.”
>
UPDATE on T-121 drug currently being developed by Thar Pharmaceuticals in Pittsburg, USA . The
FDA have given Thar approval for a Phase 3 clinical trials for their drug for CRPS; T-121 which is the oral form of Novartis’ intravenous-only zoledronic acid, which is sold under the brand name Zometra. This is
good news for CRPS sufferers however the drug won’t be entering the market until approximately 2019.
> MYCOPHENOLATE TREATMENT for LONGSTANDING COMPLEX REGIONAL PAIN SYNDROME (MYPS I) – NOW CLOSED (As of 11 January 2015) – This is a
UK study funded by the Pain Relief Foundation and sponsored by Aintree University Hospitals NHS Foundation Trust . The Chief Investigator; Dr Andreas Goebel is looking at a drug called
Mycophenolate that has only just started being used for pain as it traditionally is used for other health conditions. He believes that as it already treats the immune system and it is known that CRPS is involved in the immune system that the drug could help longstanding CRPS sufferers. When results are out they will be included on this page.
LATEST CRPS RESEARCH, STUDIES & GUIDELINES CRPS TREATMENT RESEARCH Ahmad, F.M.H. & Kumar, K.V.S.H. (2015) ‘Failure to fire after an electrical injury – a complex syndrome in a soldier,’ Mil Med Res. 2015, March 28. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440596/> doi: 10.1186/s40779-015-0036-3
Ahmed, S. et al. (2016) ‘Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Study of a Pregnant Female,’ Pain Physician. 2016, March. Vol 19(3), pp E487-493.
FULL TEXT Available from: <http://www.painphysicianjournal.com/current/pdf?article=MjYyMg%3D%3D&journal=95>
Ahmed, S.U. et al. (2015) ‘Effect of 1.5% Topical Diclofenac on Clinical Neuropathic Pain,’ Anesthesiology . 8 May 2015. PMID:
25955980. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25955980?dopt=Abstract>
Albayrak, I. et al. (2016) ‘Pulsed radiofrequency applied to the dorsal root ganglia for treatment of post-stroke complex regional pain syndrome: A case series, ‘ Journal of Clinical Anesthesia. 2016, September. Vol 33, pp 192-197. Available from: <http://www.sciencedirect.com/science/article/pii/S0952818016300952>
Alkosha, H.M. & Elkiran Y.M. (2016) ‘Predictors of long term outcome of thoracic sympathectomy in complex regional pain syndrome (CRPS ) type 2,’ World Neurosurgery. 2016, May 4. pii: S1878-8750(16)30230-3. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27155377> doi: 10.1016/j.wneu.2016.04.101. Epub ahead of print
Apiliogullari, S. et al. (2015) ‘Pulsed Radiofrequency of Dorsal Root Ganglia for the Treatment of Complex Regional Pain Syndrome in an Adolescent with Poliomyelitis Sequel: A Case Report,’ Pain Medicine. 2015. Vol 16, pp 1369-1372.
FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/16/7/1369.full.pdf>
Aradillas, E. et al. (2015) ‘Plasma Exchange Therapy in patients with Complex Regional Pain Syndrome,’ Journal of American Society of Interventional Pain Physicians . July/August 2015. Vol 18 Issue 4. pp 383-394. Available from: <http://www.painphysicianjournal.com/crrent_issue_vw.php?journal=89&code=2374&issue=current_issue>
Atalay, N.S. et al (2014) ‘Prednisolone in complex regional pain syndrome,’ Pain Physician . 2014, March-April. Vol 17(2) pp 179-185. Available
FULL TEXT from: <http://www.painphysicianjournal.com/current/pdf?article=MjA3NA%3D%3D&journal=81> PMID:
24658479
Barbalinardo, S et a;. (2015) ‘The treatment of long-standing Complex Regional Pain Syndrome with oral steroids,’ Pain Medicine . 2015, December 7. Vol 0, pp 1-7. Available FULL TEXT from: <http://painmedicine.oxfordjournals.org/content/painmedicine/early/2015/12/07/pm.pnv002.full.pdf>
Barnhoorn, K.J. et al (2015) ‘Are pain-related fears mediators for reducing disability and pain in patients with complex regional pain syndrome type 1? An explorative analysis on pain exposure physical therapy,’ NCBI NIH. 2015, 28 April; Vol 10 (4).
e0123008. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25919011> doi: 10.1371/journal.pone.0123008
Barry, M. (2016) ‘Efficacy of Pamidronate infusions for treatment of Complex Regional Pain Syndrome (CRPS),’ Prevention Care Recovery, New Zealand. Full Text Available From: <http://www.acc.co.nz/PRD_EXT_CSMP/groups/external_communications/documents/reports_results/wpc139026.pdf>
Breuer, A.J. et al. (2014) ‘Short-term treatment with parecoxib for complex regional pain syndrome: a randomized, placebo-controlled double-blind trial,’ Pain Physician. 2014, March-April. Vol 17(2) pp 127-137. Available
FULL TEXT from: <http://www.painphysicianjournal.com/current/pdf?article=MjA2OA%3D%3D&journal=81> PMID:
24658473
Chopra, P & Cooper, S. (2013) ‘Treatment of Complex Regional Pain Syndrome using Low Dose Nalterxone (LDN)’ J Neuroimmune Pharmacol. 2013 Jun; Vol 8(3) pp.470–476. Available from <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661907/> doi: 10.1007/s11481-013-9451-y
Chou, R. et al. (2009) ‘Clinical Guidelines for the Use of Chronic Opioid Therapy In Chronic Noncancer Pain’ The Journal of Pain. 2009 February; Volume 10, Issue 2. pp 113-130 e.2. Available from: <http://www.jpain.org/article/S1526-5900(08)00831-6/abstract> doi:
10.1016/j.jpain.2008.10.008>
Connolly, S.B. et al. (2015) ‘A Systematic Review of Ketamine for Complex Regional Pain Syndrome,’ Pain Medicine. 2015. Vol 16, pp 943-969.
FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/16/5/943.full.pdf>
de Oliveira, R.R. et al. (2014) ‘Thoracic sympathetic block for the treatment of complex regional pain syndrome type I: a double-blind randomized controlled study,’ Pain. 2014, November. Vol 155(11), pp 2274-2281. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25149143> doi:
10.1016/j.pain.2014.08.015
Deer, T.R. et al. (2017) ‘Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial’ Journal of International Study of Pain . 2017, April. Vol 158 Issue 4, pp 669-681. Full Text Available from: <http://journals.lww.com/pain/Fulltext/2017/04000/Dorsal_root_ganglion_stimulation_yielded_higher.14.aspx>
Douglas, S.R. et al. (2015) ‘Analgesic response to intravenous ketamine is linked to a circulating microRNA signature in female complex regional pain syndrome patients, ‘ Journal of Pain . 10 June 2015.
pii: S1526-5900(15)00700-2 Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26072390> doi: 10.1016/j.jpain.2015.05.008
Fischer, S.G.L. et al (2013) ‘Intravenous Magnesium for chronic Complex Regional Pain Syndrome Type I,’ Pain Medicine. 2013. Vol 14, pp 1388-1399. FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/14/9/1388.full.pdf>
Fukumori, S. et al (2016) ‘Assessment of Motor Function in Complex Regional Pain Syndrome With Virtual Reality-based Mirror Visual Feedback: A Pilot Case Study,’ Neuroscience and Biomedical Engineering . Volume 4, Number 1, March 2016, pp. 43-49(7) Available from: < http://www.ingentaconnect.com/contentone/ben/nbe/2016/00000004/00000001/art00007>
Gillick, L. et al. (2016) ‘Successful Treatment of Complex Regional Pain Syndrome with Pseudoaneurysm Excision and Median Nerve Neurolysis,’ World Neurosurgery. 2016, June 15, pii: S1878-8750(16)30408-9. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27318309> PMID:2731830
Goebel, A. et al. (2014) ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. 2014, October 24. Vol 15:154. Available
FULL TEXT from: <http://www.trialsjournal.com/content/pdf/1745-6215-15-404.pdf> doi:
10.1186/1745-6215-15-404.
Goebel, A. et al (2017) ‘Low-Dose Intravenous Immunoglobulin Treatment for Long-Standing Complex Regional Pain Syndrome: A Randomized Trial,’ Ann Intern Med . 2017 Oct 3. Vol 167(7); pp 476-483. Available from: <https://www.ncbi.nlm.nih.gov/pubmed/28973211>
UPDATE on Low Dose IVIG study –
Promising treatment for Complex Regional Pain Syndrome ineffective Goebel, A. et al (2014) ‘ Treatment of long-standing complex regional pain syndrome with therapeutic plasma exchange: a preliminary case series of patients treated in 2008-2014,’ Pain Med . 2014. Vol 15(12), pp 2163-2164. Available from: <http://onlinelibrary.wiley.com/doi/10.1111/pme.12601/abstract> doi: 10.1111/pme.12601 Goh, E.L. et al. (2017) ‘Complex regional pain syndrome: a recent update,’ Burns & Trauma . 2017, January 19. Vol 5, pp 5. Full Text Available From: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244710/>
Goree, J. et al. (2018) ‘New protocol for treatment of complex regional pain syndrome: a case series,’ Anesthesiology Case Reports ,
1 (1). Available from: <https://www.pulsus.com/scholarly-articles/new-protocol-for-treatment-of-complex-regional-pain-syndrome-a-case-series-4257.html>
Gierthmühlen J et al. (2014) ‘Mechanism-based treatment in complex regional pain syndrome’ Nat. Rev. Neurol. 2014 Sep; Vol 10(9) pp.518-528. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/25134708> doi: 10.1038/nreurol.2014.140. Epub 2014 Aug 19
Guisti, A, & Bianchi, G. (2015) ‘Treatment of complex regional pain syndrome type I with bisphosphonates,’ RMD Open. 2015. Vol 1 Supp 1.
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Hanlan, A.K. et al. (2014) ‘Early adjunct treatment with topical lidocaine results in improved pain and function in a patient with complex regional pain syndrome,’ Pain Physician. 2014, September-October. Vol 17(5), pp E629-635. Available
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Hendrickson, J.E. et al (2015) ‘Complex Regional Pain Syndrome and dysautonomia in a 14 year old girl responsive to therapeutic plasma exchange, ‘ J Clinical Apher. 2015, May 23. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26011726>
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Henshaw, D.S. et al. (2016) ‘Ultrasound-Guided Continuous Superficial Radial Nerve Block for Complex Regional Pain Syndrome,’ J Pain Palliat Care Pharmacother. 2016, June. Vol 30(2) pp 118-123. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27159548> doi: 10.3109/15360288.2016.1173755. Epub 2016 May 9
Hosomi, K. et al (2013) ‘Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial,’ Pain. 2013, July. Vol 154(7), pp 1065-1072. Available FULL TEXT from: <http://www.sciencedirect.com/science/article/pii/S0304395913001115> doi:
10.1016/j.pain.2013.03.016. Epub 2013 Mar 15
Imani, F. et al. (2016) ‘
Effectiveness of Stellate Ganglion Block Under Fuoroscopy or Ultrasound Guidance in Upper Extremity CRPS, ‘
Journal of Clinical and Diagnostic Research. January 2016. Vol 10, issue 1. pp UC09-UC012.
Full Text Available from: <http://www.jcdr.net/article_fulltext.asp?issn=0973-709x&year=2016&month=January&volume=10&issue=1&page=UC09&id=7035>
Kapoor, S (2012) ‘Vitamin C and its Emerging Role in Pain Management: Beneficial Effects in Pain Conditions Besides Post Herpetic Neuralgia, ‘ NCBI NIH. 2012, Jul; Vol 25 (3) pp 200-201. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389328/ > doi: 10.3344/kjp.2012.25.3.200 Published Online 28 Jun 2012
Kapural, L. et al (2016) ‘CREATE-1 study: a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of AXS-02 (disodium zoledronate tetrahydrate) administered orally to subjects with Complex Regional Pain Syndrome Type 1 (CRPS-1),’ Journal of Pain . 2016, April. Vol 17, Issue 4 Supplement. pp S81-S82. Available from: <http://www.jpain.org/article/S1526-5900(16)00436-3/pdf> doi: http://dx.doi.org/10.1016/j.jpain.2016.01.406
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Filippopulos, F.M. et al (2015) ‘Complex Regional Pain Syndrome (CRPS) or continuous unilateral distal experimental pain stimulation in healthy subjects does not bias visual attention towards one hemifield,’ Exp Brain Res . 2015, August 4. Epub ahead of print. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/26238407>
Friesgaard, K.D. et al. (2016) ‘Persistent pain is common 1 year after ankle and wrist fracture surgery: a register-based questionnaire study,’ British Journal of Anaesth. 2016, May. Vol 116(5) pp 655-661. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27106969>
Galor, A. et al. (2015) ‘Neuropathic Ocular Pain due to Dry Eye Is Associated With Multiple Comorbid Chronic Pain Syndromes,’ Journal of Pain . Published online November 2015. Available from: <http://www.jpain.org/article/S1526-5900(15)00944-X/abstract> doi: http://dx.doi.org/10.1016/j.jpain.2015.10.019
Geha, P.Y. et al. (2008) ‘The brain in chronic CRPS pain: Abnormal gray-white matter interactions in emotional and autonomic regions,’ Neuron & Pub Med . 2008, November 26. Vol 60(4). pp 570-581. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637446/> doi: 10.1016/j.neuron.2008.08.022
Giannotti, S. et al. (2016) ‘Algodystrophy: Complex Regional Pain Syndrome and incomplete forms,’ Clin Cases Miner Bone Metab . 2016, Jan-April. Vol 13(1), pp 11-14. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869945/> doi: 10.11138/ccmbm/2016.13.1.011
Goh, E.L. et al. (2017) ‘Complex Regional Pain Syndrome: A recent update’ Burns & Trauma . 2017. V5, p 2. Full Text Available from: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244710/>
Published online 2017 Jan 19. doi: 10.1186/s41038-016-0066-4
Golmirzaie, G. MD et al. (2016) ‘Time Since Inciting Event Is Associated With Higher Centralized Pain Symptoms in Patients Diagnosed With Complex Regional Pain Syndrome,’ Regional Anesthesia and Pain Medicine . November/December 2016. Vol. 41 – Issue 6: pp 731–736. Available from: <http://mobile.journals.lww.com/rapm/_layouts/15/oaks.journals.mobile/articleviewer.aspx?year=2016&issue=11000&article=00014>
Gorodkin, R. et al. (2016) ‘Microvascular response in patients with complex regional pain syndrome as measured by laser Doppler imaging,’ Microcirculation . 2016, April 26. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/27113962> Epub Ahead of Print
Hill, R.J. et al. (2012) ‘Rethinking the Psychogenic Model of Complex Regional Pain Syndrome: Somatoform Disorders and Complex Regional Pain Syndrome,’ Anesthesiology & Pain Medicine. 2012, July. Vol 2(2). pp 54-59. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821113/pdf/aapm-02-54.pdf> doi: 10.5812/aapm.7282
Hotta, J. et al. (2016) ‘Abnormal brain responses to action observation in complex regional pain syndrome,’ Journal of Pain . 2016, November. Available from: <http://www.jpain.org/article/S1526-5900%2816%2930309-1/fulltext>
Kohr, D. et al. (2011) ‘ Autoimmunity against the beta(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome,’ Pain. 2011, Dec. Vol 152(12). pp 2690-2700. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/21816540> doi: 10.1016/j.pain.2011.06.012. Krammer, H.H. (2012) ‘Immunological aspects of the complex regional pain syndrome (CRPS),’ NCBI NIH & Curr Pharm Des . (2012) Vol 18(29). pp 4546-4549 Available from: <http://www.ncbi.nlm.nih.gov/pubmed/22612752>
Kuttikat, A. et al. (2016) ‘Neurocognitive and Neuroplastic Mechanisms of Novel Clinical Signs in CRPS,’ Frontiers in Human Neuroscience . 2016, 27 January. Vol 10, p 6. Full Text Available From: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728301/>
Kuttikat, A. et al (2017) ‘Altered Neurocognitive Processing of Tactile Stimuli in Patients with Complex Regional Pain Syndrome (CRPS)’ Journal of Pain . 2017, December. Available from: <http://www.jpain.org/article/S1526-5900(17)30785-X/abstract>
Lutz, R. (2014) ‘Complex Regional Pain Syndrome may not be caused by trauma,’ MD website. 2014, July 28. Available from: <http://www.hcplive.com/medical-news/complex-regional-pain-syndrome-may-not-be-caused-by-trauma>
Mosely, L.G., & O’Connell, N.E. (2014) ‘Finding the balance in complex regional pain syndrome Expertise, optimism, and evidence,’ Neurology. Published online 2014, December. Vol 84, Issue 1. pp 19-20. Available from: < doi:
10.1212/WNL.0000000000001114
Maaike, D. et al (2015) ‘The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type 1,’ Mediators Inflamm . 2015, February.
PMCID: PMC4337272 Published online 2015, February 8. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337272/> doi: 10.1155/2015/718201
Mailis-Gagnon, A. et al. (2014) ‘Characteristics of Complex Regional Pain Syndrome in Patients Referred to a Tertiary Pain Clinic by Community Physicians, Assessed by the Budapest Clinical Diagnostic Criteria,’ Pain Medicine. 2014, December. Vol 15, pp 1965-1974.
FULL TEXT Available from: <http://painmedicine.oxfordjournals.org/content/painmedicine/15/11/1965.full.pdf>
Mainhofner, C. et al (2010) ‘Complex Regional Pain Syndromes: New pathophysiological concepts and therapies,’ Eur J Neurol. 2010, May. Vol 17 (5). pp 649-660 Available from: <http://www.ncbi.nlm.nih.gov/pubmed/20180838> doi:
10.1111/j.1468-1331.2010.02947
Marinus, J. et al. (2011) ‘Clinical features and pathophysiology of Complex Regional Pain Syndrome,’ The Lancet. 2011, July. Vol 10. Available from: <http://www.kompetenznetz-parkinson.de/mittwoch_900_1_CRPS_Lancet_Neurol_2011.pdf>
Pendon, G. et al. (2016) ‘Complex Regional Pain Syndrome type 1: Analysis of 108 patients,’ Reumatol Clin . 2016, April 28. pii: S1699-258X(16)30009-2.
Full Text Available from: <http://www.reumatologiaclinica.org/es/sindrome-doloroso-regional-complejo-tipo/avance/S1699258X16300092/>
Pepper, A. et al. (2013) ‘Complex Regional Pain Syndrome-Like Changes Following Surgery and Immobilization,’ Journal of Pain. 2013, May. Vol 14(5), pp 516-524.
FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644418/> doi: 10.1016/j.jpain.2013.01.004
Pleger, B. et al. (2014) ‘Complex Regional Pain Syndrome Type 1 affects Brain Structure in Prefrontal and Motor Cortex, ‘ PLoS One . January 2014. Vol 9(1).
e85372. Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887056/>
Ratti, C. et al. (2015) ‘Post-traumatic complex regional pain syndrome: clinical features and epidemiology,’ Clinical Cases in Mineral and Bone Metabolism . 2015-Jan-April. Vol 12 Supplement 1, pp 11-16. Full Text Available From: < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832405/>
Reimer, M et al. (2016) ‘Sensitization of the Nociceptive System in Complex Regional Pain Syndrome,’ PLoS One . 5 May 2016. Vol 11(4). e0154553.
FULL TEXT Available from: <http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0154553.PDF> doi: 10.1371/journal.pone.0154553
Schilder, J.C. et al (2015) ‘Diurnal and nocturnal skin temperature regulation in complex regional pain syndrome,’ J Pain. 2015, March. Vol 16(3). pp 207-213. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/25481495> doi:
10.1016/j.jpain.2014.11.012
Shenker, N. et al. (2015) ‘Establishing the characteristics for patients with chronic Complex Regional Pain Syndrome: the value of the CRPS-UK Registry,’ British Journal of Pain . 2015, May. Vol 9 (2) pp 122-128. Available from: <http://bjp.sagepub.com/content/9/2/122.short>
Subedi, A. et al. (2011) ‘Complex Regional Pain Syndrome (CRPS type 1) in an adolescent following Extravasation of Dextrose containing fluid – an undiagnosed case,’ Korean Journal of Pain. 2011, June. Vol 24 No.2 pp 112-114. Available from: <http://synapse.koreamed.org/Synapse/Data/PDFData/0047KJP/kjp-24-112.pdf> doi: 10.3344/kjp.2011.24.2.112
Tajerian, M. et al (2015) ‘Sex Differences in a Murine Model of Complex Regional Pain Syndrome,’ NCBI NIH & Neurobiol Learn Mem . 9 June 2015.
pii: S1074-7427(15)00107-0. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26070658> doi: 10.1016/j.nlm.2015.06.004
Tinastepe, N. (2015) ‘Complex regional pain syndrome,’ J American Dental Assoc. 2015, March. Vol 146, Issue 3. pp 200-202. Available from: < doi: 10.1016/j.adaj.2013.11.020
University of California – Davis (2015) ‘Key mechanism that causes neuropathic pain found,’ Science Daily. 7 July 2015. Available from: <http://www.sciencedaily.com/releases/2015/07/150707093353.htm>
University of Liverpool (2014) ‘Causes of serious pain syndrome closer to discovery,’ Science Daily. 2 July 2014. Available from: < http://www.sciencedaily.com/releases/2014/07/140702122531.htm>
van Velzen G.A. et al. (2016) ‘Is the brain of complex regional pain syndrome patients truly different?’ European Journal of Pain. 10 May 2016. Ahead of Print. Available from: <http://www.ncbi.nlm.nih.gov/pubmed/27161331> DOI: 10.1002/ejp.882
Varenna, M. & Zucchi, F. (2015) ‘Algodystrophy: recent insight into the pathogenic framework,’ Clinical Cases Miner Bone Metab . 2015, January – April. Vol 12(1), pp 27-30. Available
FULL TEXT from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469222/> doi:
10.11138/ccmbm/2015.12.1.027
Wild, D (2015) ‘Researchers continue to look for basic understanding of CRPS causes,’ No Pain Hanna website . 17 July 2015. Available from: <http://www.nopainhanna.com/researchers-continue-to-look-for-basic-understanding-of-crps-causes/?fb_action_ids=140180102984261&fb_action_types=rightrelevance%3Adiscover>
Zhou, G. et al. (2015) ‘Enlargement of choroid plexus in complex regional pain syndrome,’ Scientific Reports 5 .
Article number: 14329 (2015). Available FULL TEXT from: <http://www.nature.com/articles/srep14329> doi: 10.1038/srep14329
CRPS DIAGNOSIS & PROGNOSIS CRPS RESEARCH Bean, D.J. et al. (2014) ‘The Outcome of Complex Regional Pain Syndrome: A systemic Review’ The Journal of Pain. 2014, July; Vol.15 Issue 7 pp 677-690. Available from: <http://www.jpain.org/article/S1526-5900(14)00565-3/abstract> doi: 10.1016/j.jpain.2014.01.500
Bean, D.J. et al. (2015) ‘Do psychological factors influence recovery from Complex Regional Pain Syndrome Type I? A prospective study,’ Pain . 2015, July 1. Available from: < http://www.ncbi.nlm.nih.gov/pubmed/26133727> PMID:26133727
Breivik, H. & Stubhaug, A. (2016) ‘Importance of early diagnosis of Complex Regional Pain Syndrome (CRPS I and CRPS II) : Delayed diagnosis of CRPS is a major problem ,’
Scandinavian Journal of Pain . 2016. Vol 11, pp 49-51. Full Text Available from: <http://www.scandinavianjournalpain.com/article/S1877-8860(15)00129-9/pdf>
Bruehl, S. et al. (2016) ‘Complex regional pain syndrome (CRPS): evidence for warm and cold subtypes in a large prospective clinical sample,’ Pain. March 2016. Ahead of Print. Available from: <http://journals.lww.com/pain/Abstract/publishahead/Complex_regional_pain_syndrome__CRPS____evidence.99547.aspx>
Goebel, A. et al. (2014) ‘Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial,’ Trials. 2014, October 24. Vol 15:154. Available
FULL TEXT from: <http://www.trialsjournal.com/content/pdf/1745-6215-15-404.pdf> doi:
10.1186/1745-6215-15-404.
Lunden, L.K. et al. (2016) ‘Delayed diagnosis and worsening of pain following orthopaedic surgery in patients with Complex Regional Pain Syndrome (CRPS),’ Scandanavian Journal of Pain 11. 2016, pp 27-33. Full Text Available from: < http://www.scandinavianjournalpain.com/article/S1877-8860(15)00124-X/pdf>
Kuttikat, A. et al. (2017) ‘Novel Signs and Their Clinical Utility in Diagnosing Complex Regional Pain Syndrome (CRPS): A Prospective Observational Cohort Study,’ Clinical Journal of Pain .
June 2017 – Volume 33 – Issue 6 – p 496–502
COMPLICATIONS OR SIDE EFFECTS of CRPS Lee, D.H. et al (2014) ‘Risk Factors for Suicidal Ideation among Patients with Complex Regional Pain Syndrome,’ Psychiatry Investigation . 2014, January. Vol 11(1) pp 32-38. Available
FULL TEXT from: <http://psychiatryinvestigation.org/html/fulltext.asp?no=0502014005&m=0> doi:
10.4306/pi.2014.11.1.32. Epub 2013 Oct 16
Qureshi, A.A. & Friedman, A.J. (2018) “Complex Regional Pain Syndrome: What the Dermatologist Should Know,” Journal of Drugs in Dermatology. May 2018. Vol 17, Issue 5, pp 532. Available from: < http://jddonline.com/articles/dermatology/S1545961618P0532X>
Schwartzman, R.J. (2012) ‘Systemic Complications of Complex Regional Pain Syndrome,’ Neuroscience & Medicine . 2012. Vol 3. pp 225-242. Available from: <http://file.scirp.org/Html/22695.html> doi: 10.4236/nm.2012.33027
CRPS in CHILDREN Boyraz, I. et al (2016) ‘A Child Patient Followed-up with the Diagnosis of Recurrent Complex Regional Pain Syndrome,’ Turkish Journal of Osteoporosis . 2016. Vol 22, pp 47-9. Full Text Available from: <http://cms.galenos.com.tr/FileIssue/9/945/article/47-49.pdf>
Dietz, F.R. & Compton, S. (2015) ‘Outcomes of a Simple Treatment for Complex Regional Pain Syndrome Type I in Children,’ Iowa Orthop Journal . 2015. Vol 35, pp 175-180. FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492150/pdf/IOJ_2015_175.pdf>
Gharaei, H. (2015) ‘Continuous Peripheral Nerve Catheters in Pediatric Complex Regional Pain Syndrome,’ Anesth Pain Med . 2015, February. Vol 5 (1)
e23414. Available from: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350163/> doi: 10.5812/aapm.23414
Leuthold, B. et al. (2015) ‘Severe complex regional pain syndrome (CRPS) type I: A multidisciplinary treatment plan and intensive physiotherapy in pediatrics,’ Annals of Physical and Rehab Medicine . 2015, September. Vol 58 Supplement 1 pp e140. Available from: <http://www.sciencedirect.com/science/article/pii/S1877065715004169>
Parker, R. et al (2018) “An Integrative Review of Interventions to Support Parents When Managing Their Child’s Pain at Home “ Pain Management Nursing . April 2018. Vol 19, Issue 2, Pages 139-156. Available from: <https://www.sciencedirect.com/science/article/pii/S1524904217303417>
Pedemonte, S. et al (2015) ‘Complex regional pain syndrome type i. An analysis of 7 cases in children,’ Neurologia. 2015, July-August. Vol 30(6), pp 347-351. Available
FULL TEXT from: <http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=90434137&pident_usuario=0&pcontactid=&pident_revista=495&ty=103&accion=L&origen=zonadelectura&web=www.elsevier.es&lan=en&fichero=495v30n06a90434137pdf001.pdf> doi:
10.1016/j.nrl.2013.12.016. Epub 2014 Jun 18
Rodriguez-Lopez, M.J. et al (2015) ‘Complex Regional Pain Syndrome in Children: a multidisciplinary approach and Invasive Techniques for the management of nonresponders,’ Pain Practice . 2015, 11 June. Available from: <http://onlinelibrary.wiley.com/enhanced/doi/10.1111/papr.12317/>
doi: 10.1111/papr.1231
Rodriguez, M.J. et al. (2015) ‘Invasive Management for Pediatric Complex Regional Pain Syndrome: Literature Review of Evidence,’ Pain Physician. 2015, Nov. Vol 18(6), pp 621-630.
FULL TEXT Available from: <http://www.painphysicianjournal.com/current/pdf?article=MjQ1OA%3D%3D&journal=92>
Saltik, S. et al. (2016) ‘Pregabalin Treatment of a Patient With Complex Regional Pain Syndrome,’ Paediatric Neurol. 2016, January. Vol 54, pp 88-90.
FULL TEXT Available from: <http://www.pedneur.com/article/S0887-8994(14)00016-2/pdf> doi: 10.1016/j.pediatrneurol.2014.01.015
Stevenson Won, A. (2015) ‘A Virtual Balloon-Popping Task for Kids with CRPS,’ Body In Mind website . 25 August 2015. Available from: <http://www.bodyinmind.org/virtual-reality-kids-crps/>
Wager, J. et al. (2015) ‘Psychological distress and stressful life events in pediatric complex regional pain syndrome,’ Pain Res Management. 2015, July-August. Vol 20(4), pp 189-194. Available
FULL TEXT from: <http://www.pulsus.com/journals/pdf_frameset.jsp?jnlKy=7&atlKy=13480&isArt=t&jnlAdvert=Pain&adverifHCTp=&sTitle=Psychological%20distress%20and%20stressful%20life%20events%20in%20pediatric%20complex%20regional%20pain%20syndrome%2C%20Pulsus%20Group%20Inc&VisitorType=&pdfType=fulltextpdf>
Epub 2015 Jun 2.#
Weissman, R. & Uziel, Y. (2016) ‘Pediatric complex regional pain syndrome: a review,’ Pediatr Rheumatol Online Journal. 2016, April 29. Vol 14(1) pp 29. Full Text Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850724/> doi: 10.1186/s12969-016-0090-8
AMPUTATION and CRPS Amputation for Complex Regional Pain Syndrome still remains a
very controversial subject amongst the medical and legal communities. If you’d like to read our article on
Amputation for CRPS please visit
‘Is Amputation for CRPS Really A Cure?’
Here are some CRPS research studies about amputation:
Bodde, M.I. et al. (2014) ‘Informed Decision-Making Regarding Amputation for Complex Regional Pain Syndrome Type I,’ Journal of Bone Joint Surgery Am. 2014. Vol 96, pp 930-4. Full Text Available from: <https://www.researchgate.net/profile/Jan_Geertzen/publication/262847014_Informed_Decision-Making_Regarding_Amputation_for_Complex_Regional_Pain_Syndrome_Type_I/links/53f712670cf22be01c4530ae.pdf>
Bodde, M.I. et al. (2014) ‘Resilience in patients with amputation because of Complex Regional Pain Syndrome type I,’ Disability and Rehabilitation. 2012. Vol 36 issue 10, pp 838-843. Full Text Available from: <https://www.researchgate.net/profile/Pieter_Dijkstra2/publication/255732128_Resilience_in_patients_with_amputation_because_of_Complex_Regional_Pain_Syndrome_type_I/links/543f94e60cf23da6cb5b39c8.pdf>
Geertzen, J.H.B. et al. (2014) ‘Peripheral nerve pathology in patients with severely affected complex regional pain syndrome type I,’ International Journal of Rehabilitation Research. 2014. Full Text Available from: <https://www.researchgate.net/profile/Jan_Geertzen/publication/268984263_Peripheral_nerve_pathology_in_patients_with_severely_affected_Complex_regional_pain_syndrome_type_I/links/54d9ed480cf25013d0436bec.pdf>
Midbari, A. et al. (2016) ‘Amputation in patients with Complex Regional Pain Syndrome – a comparative study between amputees and non-amputees with intractable disease,’ The Bone and Joint Journal. 2016, April. Available from: <>http://www.bjj.boneandjoint.org.uk/content/98-B/4/548
GUIDELINES for CRPS NETHERLANDS – Netherlands Society of Anaesthesiologists & Netherlands Society of Rehabilitation Specialists (November 2014) ‘Updated EBGD Guidelines for Complex Regional Pain Syndrome Type 1 2014,’ Full Guidelines Available from: <http://pdver.atcomputing.nl/pdf/Executive_summary_updated_guidelines_CRPS_I_2014.pdf>
UK – Royal College of Physicians 2nd Edition (July 2018) ‘UK Guidelines for diagnosis, Referral & Management in Primary & Secondary Care, Complex Regional Pain Syndrome in Adults,’ Available from: <
https://www.rcplondon.ac.uk/resources/complex-regional-pain-syndrome-guidelines >
USA – American Academy of Pain Medicine (2013) ‘Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 4th Edition, ‘ Pain Medicine . 2013, Vol 14. pp 180-229. Available from: <http://onlinelibrary.wiley.com/doi/10.1111/pme.12033/epdf>
Latest News of Studies for CRPS/RSD
Latest News for CRPS/RSD
CRPS and CHRONIC PAIN NEWS ARTICLES PAIN MANAGEMENT & TREATMENT Ansorge, R. 20th March 2015 ‘Ozone Therapy: Hope for Chronic Illness’ Newsmax Health. Available from: <http://www.newsmax.com/Health/Health-News/ozone-therapy-treatment-cancer/2015/03/20/id/631395/>
Buxton, S. 7 October 2016 ‘Exploring patients’ opinions of activity pacing and a new activity pacing questionnaire for chronic pain and/or fatigue: a qualitative study,’ PhysioSpot . Available from: <http://www.physiospot.com/research/exploring-patients-opinions-of-activity-pacing-and-a-new-activity-pacing-questionnaire-for-chronic-pain-andor-fatigue-a-qualitative-study/>
Coghlin, Ed 10th April 2105. ‘ WHAT IS THE STATE OF PAIN MANAGEMENT? National Pain Report. Available from: <http://nationalpainreport.com/what-is-the-state-of-pain-management-8825926.html>This article from the
National Pain Report following the
National Institutes of Health chronic pain strategy. In this they ask some expert doctors to comment on the question
‘What is the state of pain management?’ Read the article to discover more.
Deer, T.R. et al. (2015) ‘Case Report 7: Dorsal Root Ganglion Stimulation for The Treatment of Neuropathic Foot And Hand Pain,’ Pain Medicine News website . 2015, December 28. Available from: <http://painmedicinenews.com/Review-Articles/Article/12-15/Case-Report-7-Dorsal-Root-Ganglion-Stimulation-for-The-Treatment-of-Neuropathic-Foot-And-Hand-Pain/34540>
Drummond, P. (2015) ‘Sympathetic blocks for complex regional pain syndrome,’ Body In Mind website . 1 May 2015. Available from: <http://www.bodyinmind.org/sympathetic-blocks-crps/>
Frei, R. April 2015 Vol.13(4). ‘More Novel Technologies emerging in SCS’ Pain Medicine News . Available from: <http://www.painmedicinenews.com/ViewArticle.aspx?ses=ogst&d=Interventional+Pain+Medicine&d_id=353&i=April+2015&i_id=1167&a_id=30933#.VSZmYFCPhho.facebook> The world of
Spinal Cord Stimulators is beginning to become a large target market for research companies wanting better SCS products for the large number of sufferers worldwide.
Leung, M. April 2015 Vol 13(4). ‘Risk Factors Elucidated for early dose Escalation in Long Term Opioid Therapy’ Pain Medicine News .
Available from: < http://www.painmedicinenews.com/ViewArticle.aspx?ses=ogst&d=Clinical+Pain+Medicine&d_id=82&i=April+2015&i_id=1167&a_id=30932#.VSZm1A0KhPE.facebook>
Mangione, A.S. et al. (2016) ‘Nonparalytic botulinum molecules for the control of pain,’ Pain. May 2016.Vol 157. Issue 5, pp 1045-1055.
FULL TEXT Available from: <http://journals.lww.com/pain/Fulltext/2016/05000/Nonparalytic_botulinum_molecules_for_the_control.9.aspx?platform=hootsuite> doi: 10.1097/j.pain.0000000000000478
Pearlman, J. 15 October 2015. ‘Cure for chronic pain found: World’s first as patient fitted with permanent spinal cord implant,’ Telegraph news online . Available from: <http://www.telegraph.co.uk/news/worldnews/australiaandthepacific/australia/11932938/Cure-for-chronic-pain-found-World-first-as-patient-fitted-with-permanent-spinal-cord-implant.html>
Straube, S. et al. 6th May 2015. ‘Vitamin D for the treatment of chronic painful conditions in adults,’ Cochrane. Available from: <http://www.cochrane.org/CD007771/SYMPT_vitamin-d-for-the-treatment-of-chronic-painful-conditions-in-adults?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+NewAndUpdatedSummaries+%28New+and+updated+Cochrane+summaries%29>
Stevenson Won, A. (2015) ‘A Virtual Balloon-Popping Task for Kids with CRPS,’ Body In Mind website . 25 August 2015. Available from: <http://www.bodyinmind.org/virtual-reality-kids-crps/>
PATHOPHYSIOLOGY & SPREADING of CRPS Denk, F et al (2016) ‘Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain ,’ Cell Reports. FULL TEXT Available from: <http://www.cell.com/cell-reports/pdf/S2211-1247(16)30507-1.pdf> doi: http://dx.doi.org/10.1016/j.celrep.2016.04.063
Galor, A. et al. (2015) ‘Dry Eye’ Lined to Chronic Pain Syndromes,’ University of Miami Miller School of Medicine . December 2015. Available from: <http://med.miami.edu/news/dry-eye-linked-to-chronic-pain-syndromes>
Goebel, A. (2015) ‘Specific autoantibodies in patients with longstanding CRPS,’ Body In Mind website. 7th July 2015. Available from: < http://www.bodyinmind.org/autoantibodies-crps/>
Gordon, D. (2009) ‘More than a Feeling,’ Neurology Now . 2009, March/April. Vol 5 Issue 2. pp 18-19, 23-25. Available from: <http://journals.lww.com/neurologynow/Fulltext/2009/05020/More_Than_a_Feeling.17.aspx> doi:
10.1097/01.NNN.0000351335.65015.f4
King’s College, London. 12 May 2016. ‘Cells carry ‘memory’ of injury, which could reveal why chronic pain persists,’ KCL website . Available from: <http://www.kcl.ac.uk/ioppn/news/records/2016/May/Cells-carry-memory-of-injury,-which-could-reveal-why-chronic-pain-persists.aspx>
Schwartzman, R. MD 1st April 2013. ‘Complex Regional Pain Syndrome: Systemic Complications’ Practical Pain Management. Available from: <http://www.practicalpainmanagement.com/pain/complex-regional-pain-syndrome-systemic-complications> This article by a medical doctor is a very interesting and detailed article discussing the areas of the body that can be affected by CRPS/RSD such as the heart, chest pain, respiratory and others.
Schwartzman, R. MD 1 March 2010. ‘Deconstructing Complex Regional Pain Syndrome’ Practical Pain Management. Available from: <http://www.practicalpainmanagement.com/pain/neuropathic/crps/deconstructing-complex-regional-pain-syndrome> This article talks of the progression in the understanding of the basics of CRPS which may eventually take researchers to new medication and treatment.
Saint Louis University Medial Center 16 April 2015 ‘SLU Researchers Show that A3 Adenosine Receptor Can Activate “Off Signals” for Pain ‘ Newswise. Available from : <http://www.newswise.com/articles/slu-researchers-show-that-a3-adenosine-receptor-can-activate-off-signals-for-pain#>
MISCELLANEOUS Bean, D. (2015) ‘Could your state of mind influence CRPS recovery?’ Body In Mind website . 9th October 2015. Available from: <http://www.bodyinmind.org/factors-affecting-crps-recovery/>
Coole, C. et al. (2013) ‘Supporting Workers with Musculoskeletal Conditions: A Survey of United Kingdom Occupational Therapists’ Communications with Clients and Their Employers,’ British Journal of Occupational Therapy .
November 2013. V ol. 76 no. 11 478-486. Available from: <http://bjo.sagepub.com/content/76/11/478.abstract>
Fiore, K. 4th April 2015. ‘IS PAIN A PUBLIC HEALTH CRISIS? ‘ MedPage Today. Available from: <http://www.medpagetoday.com/PainManagement/PainManagement/50826> This is an interesting article by
MedPage Today , about whether chronic pain is a public health crisis in the USA. However the same question could be applicable around the world, what are your thoughts?
Is Pain A Public Health Crisis? Farell, J. (7th April 2015) ‘Hidden Disabilities and employer obligations under DDA ‘ HR.BLR.COM(R) 2015 April. Available from: <http://hr.blr.com/HR-news/Discrimination/Disabilities-ADA/Hidden-disabilities-employer-obligations-under-ADA#> This is a good article written by a lawyer which outlines the employer obligations under the USA DDA about hidden disabilities of which CRPS/RSD is one.
Goebel, A. (2014) ‘Chronic Pain isn’t all in the brain, which is good news for sufferers,’ The Conversation. 2014, November 25. Available from: <http://theconversation.com/chronic-pain-isnt-all-in-the-brain-which-is-good-news-for-sufferers-34632>
Hannibal, K.E. & Bishop, M.D. (2014) ‘Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation,’ Physical Therapy. 2014, December. Vol 94(12), pp 1816-1825.
FULL TEXT Available from: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/?report=reader>
Jackson, T. et al. (2012) ‘Light Retrograde Massage for the Treatment of Post-Stroke Upper Limb Oedema: Clinical Consensus Using the Delphi Technique,’ British Journal of Occupational Therapy . December 2012. V ol. 75 no. 12 549-554. Available from: <http://bjo.sagepub.com/content/75/12/549.abstract>
Malcangio, M. (2016) ‘Microglia and Chronic Pain,’ Pain . May 2016. Vol 157 Issue 5, pp. 1002-1003.
FULL TEXT Available from: <http://journals.lww.com/pain/Fulltext/2016/05000/Microglia_and_chronic_pain.4.aspx?platform=hootsuite> DOI: 10.1097/j.pain.0000000000000353 This article concluded that:
“Further studies comparing and contrasting microglial mechanisms in peripheral nerve injury and inflammation will help delineate shared and specific pathways for chronic pain conditions. At the same time, this line of research will yield innovative targets for the development of analgesic therapies for patients’ benefit.”
We hope you have found this page interesting for the
Latest CRPS Research in the world . Research evolves and updates very quickly and all of the time. This page highlights the most important latest CRPS research that is available.
**Burning Nights CRPS Support is not responsible for any external links found within this website. We do not endorse any 3rd party business or website, they are suggestions only. Please seek medical advice from your doctor before trying anything new or different to your usual regime.**
Last Updated: 15/01/2019
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